Related Gene(s): BRCA1, BRCA2, EPCAM*, MLH1, MSH2, MSH6, PMS2, PTEN, TP53
GYNplus is a next generation sequencing (NGS) panel of 13 genes associated with an increased risk for ovarian and/or uterine cancer (BRCA1, BRCA2, BRIP1, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, PTEN, RAD51C, RAD51D, and TP53). These thirteen genes all have available management guidelines. Identification of a mutation in one of these genes can help estimate cancer risk and guide treatment, screening, and/or prevention decisions for the patient. Family members can be tested for the familial mutation to determine if they have an increased risk (positive for the familial mutation) or average risk (negative for the familial mutation) for cancer. Many individuals with a personal and/or family history of ovarian and/or uterine cancer may also have a personal and/or family history of breast and/or colorectal cancer and may be suspicious for more than one of the above syndromes. GYNplus may be ideal for such families.
This test will be available soon. For additional information, please contact us.