Related Gene(s): ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MRE11A, MUTYH, NBN, NF1, PALB2, PTEN, RAD50, RAD51C, RAD51D, TP53

Breast cancer is the most common cancer in women in developed countries, affecting about 1 in 8 (12.5%) women in their lifetime. The National Cancer Institute (NCI) estimates that approximately 231,840 new cases of female breast cancer will be diagnosed in the U.S. in 2015. The majority of breast cancers are sporadic, but 5-10% are due to inherited causes. Hereditary breast cancers tend to occur earlier in life than non-inherited sporadic cases and are more likely to occur in both breasts. The highly penetrant genes, BRCA1 and BRCA2, appear to be responsible for around half of hereditary breast cancer. However, additional genes have been discovered that are associated with increased breast cancer risk as well. Mutations in the genes on the BreastNext panel can confer an estimated 20–87% lifetime risk for breast cancer. Some of these genes have also been associated with increased risks for other cancers, such as pancreatic cancer with PALB2, ovarian cancer with BRCA1, BRCA2, RAD51C, and others, and sarcoma with TP53.

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