TP53

TP53 encodes the transcription factor Tp53, which is a tumor suppressor involved in cell cycle arrest and apoptosis, and is the most frequently mutated gene in cancer. Simple variants in TP53 are seen in about 33% of all tumors. Germline variants in TP53 cause the Li-Fraumeni Syndrome. Mutations in TP53 have been implicated in chemoresistance.