Maple Syrup Urine Disease, Type 1a (BCKDHA)
Maple syrup urine disease, type 1a is an autosomal recessive disorder that is caused by pathogenic variants in the gene BCKDHA. While it is found in different ethnicities around the world, it is more prevalent in certain Mennonite communities and the Roma population in Portugal, due to the presence of founder mutations. There are several different presentations of maple syrup urine disease, but the most common, and the most severe, is the classic infantile presentation. Affected infants cannot break down certain amino acids, and buildup of toxic metabolites occurs and gives the urine a sweet scent. Without intervention, affected infants will experience vomiting and lethargy and will develop seizures and ataxic movements. Progression to coma and death within the first weeks of life will occur if untreated. Although dietary management of the disease is possible, the outcome is unpredictable and a significant portion of affected individuals are mentally impaired or experience neurological complications. Some patients may have a later onset of symptoms, but the disease may still cause brain damage or death. It is not currently possible to predict the severity of the disease based on the genotype.
|Disease Name||Gene||Guaranteed Exons||Inheritance||Ethnicity||Carrier Frequency||Detection Rate||Residual Risk|
|Maple Syrup Urine Disease, Type 1a||BCKDHA||2-9  (*19)||AR||Caucasian||1 in 320||36%||0.00200400801603206|
|Maple Syrup Urine Disease, Type 1a||BCKDHA||2-9  (*19)||AR||Worldwide||1 in 289||45%||0.0019047619047619|
|Maple Syrup Urine Disease, Type 1a||BCKDHA||2-9  (*19)||AR||Mennonite||1 in 10||>95%||0.00552486187845304|
|Maple Syrup Urine Disease, Type 1a||BCKDHA||2-9  (*19)||AR||Portuguese Roma||1 in 71||>95%||0.000713775874375446|